Identifying the Issue
- Cancer is the most feared and deadly disease worldwide
- Treatment of cancer is limited because of the limited functional molecules available
Objective of the Research
- To synthesize novel acetal derivatives of arjunolic acid and to study their anti-cancer properties
Who should read this?
Research community working in anti-cancer drug development, medicinal chemists, and pharmaceutical industry
Solution
Development of nontoxic small molecules with high therapeutic effect and selectivity
Key Features and Benefits
- The synthesized acetals of arjunolic acid show promising anti-cancer properties
- Arrest the cell cycle of cancer cells at the G2/M phase
- These compounds have better anti-cancer properties than arjunolic acid
Impact
- Potent compounds from this study have better anti-cancer properties than the parent compound arjunolic acid
- Effective against colon cancer
- Lead compounds from this study offer new and more effective treatment options for colon cancer
Team
Manohar Bhujel, Lakshminath Sripada, Bhuvanesvaragurunathan K., Pandikumar Perumal, Dolly Jain, Nishant Pandey, Avinash Bajaj, Nageswara Rao Golakoti
Title of paper: “Synthesis and anti-cancer activity of acetals of arjunolic acid”
Read Paper Here: https://doi.org/10.1002/slct.202401675
