Identifying the Issue
- Off-target effects of the anti-cancer drugs available in the market.
- Need for better anti-cancer drugs with high potency and low toxicity.
Objective of the Research
- To synthesize novel Spirobibenzopyrans with potent anti-cancer activity. \
- this study focuses on creating compounds with powerful anti-cancer properties while minimizing toxicity
Who should read this?
Research community working in cancer drug discovery and development, medicinal chemists, and the pharmaceutical industry.
Solution
Design and synthesis of Spirobibenzopyrans with potent anti-cancer activity
Key Features and Benefits
- One pot synthesis of Spirobibenzopyrans using Lewis acid catalysts.
- Screening of anti-cancer activity of the synthesized Spirobibenzopyrans by a phenotypic approach.
- HIT compounds identified.
- Toxic dose determined in Drosophila
Impact
- Potent compounds 5-methoxyspirobibenzopyran and 6-methoxybibenzopyran act as potent pJNK inhibitors. pJNK is an oncogenic target.
- The correlation between the docking studies and the experimental studies were established.
Team
- Dr. Prashant Rai, Department of Chemistry, Sri Sathya Sai Institute of Higher Learning
- Dr. Rohit Kumar, Department of Biochemistry, Institute of Science, Banaras Hindu University
- Jyotsna Singh, Department of Biochemistry, Institute of Science, Banaras Hindu University
- Prof. Srikrishna Saripella, Department of Biochemistry, Institute of Science, Banaras Hindu University,
- Prof. Nageswara Rao Golakoti, Department of Chemistry, Sri Sathya Sai Institute of Higher Learning
Title of paper: Design, synthesis, in-vitro, and in-vivo anti‐cancer evaluation of the novel spirobibenzopyrans on epithelial cancer model of Drosophila melanogaster
Read Paper Here: https://link.springer.com/article/10.1007/s11696-022-02321-x
